Opening Day 2025 Reds Baseball. Major league baseball announcing its 2025 schedule today, the redbirds will play the san francisco giants here at home on thursday, march. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati.

The cincinnati reds now know their opening day opponent for next season as major league baseball released the team’s schedule for 2025. Besides the cubs and dodgers, 26 other teams will celebrate opening day on thursday, march 27.